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Information × Registration Number 0226U001450, (0123U100755) , R & D reports Title To study the dose-dependent features of modeling hypometabolism and hypothermia in a hypoxic-hypercapnic environment and to develop the technology of its application for the rehabilitation of war victims popup.stage_title Вивчити дозо-залежні особливості моделювання гіпометаболізму і гіпотермії у гіпоксично-гіперкапнічному середовищі та розробити технологію його застосування для реабілітації постраждалих внаслідок війни Head Muradyan Khachik K., Доктор біологічних наук Registration Date 27-01-2026 Organization D. F. Chebotarev Institute of Gerontology of the National academy of the medical sciences of Ukraine popup.description1 The inverse relationship between the rates of metabolic processes and aging is one of the fundamental laws of gerontology. That is why the controlled decrease in the intensity of metabolism and body temperature with the help of a hypoxic-hypercapnic environment (HGS) is an evolutionarily consistent mechanism for reducing the frequency of age-related pathology and prolonging life. An important and still unsolved problem remains the selection of such conditions of HGS, which would ensure the maximum decrease in the intensity of metabolic processes with minimal trauma to the experimental animals. A successful solution to this problem would open perspectives for the recommendation of the studied model of hypometabolism for subsequent clinical trials. Along with previously tested "hard" models of HGS, which showed high efficiency of their application on laboratory animals, it is planned to study the possibility of creating more "soft" models of hypometabolism and hypothermia. popup.description2 In experimental models, using physiological, biochemical and molecular genetic methods, balanced modes of influence were worked out, ensuring a decrease in the intensity of metabolic processes without signs of organ toxicity; genetic screening was carried out to identify genes that mediate the positive effects of interval hypoxic training on aging and the development of age-related pathology, and recommendations were prepared for scaling the model to clinical trials. It was established that chronic retention in a hypoxic-hypercapnic environment is accompanied by a decrease in body and liver weight, a decrease in plasma glucose and triglyceride levels, and the accumulation of lactate in the brain, which is interpreted as a decrease in metabolic intensity and activation of the astrocyte-neuronal lactate shuttle. The obtained data confirm the concept of the hormetic effect of ROS oscillations during interval hypoxia as a trigger of long-term transcriptional and epigenetic programs, indicate the existence of a developmental “window of plasticity” and substantiate the prospects of non-drug approaches to slowing the rate of aging and preventing neurodegenerative changes; the created model can serve as the basis for the development of clinical rehabilitation schemes and scaling up the technology for use in military challenges. Product Description popup.authors Koshel Natalya M Zoia O. Serebrovska Dubiley Tetyana Oleksiivna. Sykalo Nina V. Migovan Svitlana A Rushkevych Yuriy Ye Mykhaylo R. Hetsuriani Tolstun Denys Oleksandrovych Maksymchuk Oksana V Illia M. Fakhridinov Danylo O. Kybenko popup.nrat_date 2026-01-27 Close