Registration Number
0226U001667,
(0123U101245)
, R & D reports
Title
Study of the effect of anticoagulants on the processes of metastasis and the effectiveness of antitumor therapy (experimental research)
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Дослідження впливу антикоагулянтів непрямої дії (Неодикумарин) на метастатичну активність епідермоїдної карциноми легенів Льюїс
Head
Karatsuba Tetiana A., Кандидат біологічних наук
Registration Date
29-01-2026
Organization
Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
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To investigate in an experiment the effect of anticoagulants of direct and indirect action on the processes of metastasis under the conditions of the use of antitumor agents.
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The conducted experiments revealed a significant decrease in the metastatic activity of Lewis lung carcinoma (LLC) under the conditions of acenocoumarol administration. Acenocoumarol inhibited both the formation of metastases and their growth. Acenocoumarol showed a slight antitumor effect on LLC, but significantly affected the lifespan of animals with LLC: the increase in average lifespan was 26.4%, which is above the criterion of significance for this tumor (> 25%). The administration of acenocoumarol had a positive effect on animals with impaired blood coagulation activity on the background of LLC: the blood clotting time of animals administered acenocoumarol increased compared to animals without treatment. The study of platelet hemostasis of experimental animals with LLC revealed a significant decrease in the content of platelets in venous blood and a certain decrease in megakaryocytes in the bone marrow compared to similar indicators in animals without tumors. Acenocoumarol increases platelet and megakaryocyte counts in animals with LLC compared to untreated animals.
Product Description
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Olha O. Khavych
Oleksii M. Puskov
Maksym A. Munko
Serhii V. Maksiuta
Denys O. Cherviovskyi
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2026-01-29
