Search academic texts

Information × Registration Number 0226U001724, (0124U000717) , R & D reports Title Investigation of the anti-virulence effects of antimicrobals popup.stage_title Вивчення експресії генів вірулентності у Pseudomonas aeruginosa за дії макролідів і похідних арилаліфатичних аміноспиртів та їх вплив на специфічну активність антимікробних препаратів Head Vrynchanu Nina O., Registration Date 30-01-2026 Organization Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine popup.description1 To substantiate the approaches of containment of antibiotic resistance of microorganisms by reducing their virulence under the action of macrolides and derivatives of arylaliphatic amino alcohols popup.description2 The results of the studies have shown that macrolides and derivatives of arylaliphatic amino alcohols are able to affect QS-dependent virulence factors of P. aeruginosa, changing the transcriptional activity of the lasI, lasR, pqsR and rhlR genes, which regulate the functioning of intercellular interaction systems, the aprA, exoS, exoA and toxA genes, which are responsible for the synthesis of exotoxins, and the algD, algL, algR, algU genes, which regulate the synthesis of structural components of the Pseudomonas aeruginosa biofilm. Azithromycin and clarithromycin are able to affect the sensitivity of multi-resistant Pseudomonas aeruginosa strains to antimicrobial drugs, both increasing and decreasing them, depending on the test strain and antimicrobial drug. Product Description popup.authors Tetiana A. Bukhtiarova Liubov B. Zelena popup.nrat_date 2026-01-30 Close