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Information × Registration Number 0226U001975, (0121U108204) , R & D reports Title 622. The changes of micro-/ultramicroscopic and histochemical properties of tissues during compensatory-adaptive reactions popup.stage_title Особливості змін мікро-/ ультрамікроскопічної структури та гістохімічних властивостей тканин організму під час розвитку компенсаторно-пристосувальних реакцій. Head Tiron Oksana , к.мед.н. Registration Date 04-02-2026 Organization Odessa National Medical University popup.description1 To establish the micro-/ ultramicroscopic and histochemical features in thyroid gland in rats at different periods after the experimental thermal burn injury (in 1, 3, 7, 14, 21, 30 days after the burn) under conditions of intravenous infusion of hyperosmolar solutions (lactoprotein with sorbitol and gekoton). popup.description2 First from data of flow cytometry bring in ginis validified to pathogeny of defeat of thyroid gland at the burn of skin, that causes the disbalance of indexes of synthesis of DNA and apoptosis in the cages of thyroid gland and has maximal expressed on 3th to twentyfour hours after the thermal damage of skin. The set changes answer an apoptosis with the simultaneous maximal decline of synthesis of DNA that testifies to the expressed influence on the organism of toxic metabolits. Normalization of the investigated indexes of cellular cycle and fragmentation of DNA of tyrocytes is first wellproven under act of application of hyperosmolar solutions of lactoprotein with a glucitol or HAES - LX - 5 beginning from 21 time of post-burn process. It is expedient to conduct the clinical laboratory inspection of function of thyroid gland for patients with burns with the aim of early exposure of thyroid and timely pharmacological therapies. Product Description popup.authors Oksana I. Tiron Iryna I. Kuvshynova Ruslan S. Vastianov Olena O. Markova Oleksandra O. Liashevska Volodymyr Y. Brieus popup.nrat_date 2026-02-04 Close