Registration Number
0226U002421,
(0123U104577)
, R & D reports
Title
Development of scientifically based approaches to the diagnosis, treatment and control of curability of patients with syphilitic infection during the war period
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Розробка науково обґрунтованих підходів до діагностики, лікування та контролю за виліковністю хворих із сифілітичною інфекцією у воєнний період
Head
Bondarenko Hlib M., Доктор медичних наук
Registration Date
24-02-2026
Organization
State institution "Institute of Dermatology and Venereology of NAMS of Ukraine"
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To investigate the informativeness of the indicators of immunoglobulins to Treponema pallidum as diagnostic criteria of the disease and to develop, on the basis of laboratory studies, approaches to choosing the optimal amount of treatment in conditions of war
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Purpose of the research: To investigate the informativeness of immunoglobulin indices to Treponema pallidum as diagnostic criteria for the disease and to develop, based on laboratory studies, approaches to choosing the optimal volume of treatment in war conditions. Object of study: serum, cerebrospinal fluid, patients. As a result of the studies of 1357 serum samples obtained from patients by the RPGA-Trep method, positive results were obtained in qualitative formulation for the detection of specific antibodies to T. pallidum in 36.7% of cases; in 69.3% (4+) positive samples in the semi-quantitative version, which allows for further monitoring of the dynamics of antibody formation. When examining 169 serum samples and 13 cerebrospinal fluid from patients with various forms of syphilis in ELISA Different, syphilitic infection with positivity from 4, 3, 2 proteins ( Tr15, Tr17, Tr41, Tr47 ) in various combinations was established in 117 ( 64.3%) patients, which made it possible to carry out a probable differentiation of early, late latent, unspecified forms of syphilis, neurosyphilis and to exclude the active form of infection in 65 (35.7%) patients.
The proposed method of treatment of early forms of syphilis with the use of ceftriaxone intravenously 2.0 g 1 time per day (or 1.0 intramuscularly 2 times a day) for 14 days and pentoxifylline 200 mg 3 times a day for 20 days was effective in 100% of patients. The use of this method in the presence of contraindications to penicillin therapy, procaine or in the absence of these drugs is promising, pathogenetically justified. It is easy to use and suitable for a day hospital, which makes it convenient, economically justified and accessible to a wide range of patients, which is very relevant in wartime conditions.
Product Description
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Hanna P. Holub
Nikitenko Inna M.
Olexei A. Bezruchenko
Gubenko Tetyana V.
Olha M. Bilokon
Liudmyla I. Pieieva
Valentyna Volkoslavska
Valentyna Kutova
Hanna K. Kondakova
Olena O. Yereshchenko
Serhii Unuchko
Nataliia B. Kurylo
Andrii S. Huriev
Eduard Khoroshun
Tetiana V. Dehtiar
Olena I. Dobrodieieva
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2026-02-24
