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Information × Registration Number 0301U000678, 0100U003382 , R & D reports Title To determinate mineral and organic phases structure changes and rebuilding of DNA in development of radioinduced oncohaematologycal pathology and allied deseases of victims by Chernobyl accident in distant period popup.stage_title Дослідити експресію пухлинноасоційованих онкогенів, рівень метилювання ДНК в пухлинному субстраті, рівень ДНК-аз у сироватці і сечі, одно- та двониткові розриви ДНК у постраждалих з радіоіндукованими лейкеміями та спорідненими захворюваннями у віддалений період після аварії на ЧАЕС. Head Bebeshko Volodymyr Grygorovych, Доктор медичних наук Registration Date 23-04-2001 Organization Research Centre for Radiation Medicine popup.description2 Object of research - 119 children and adult with leukemias and related diseases of the Chernobyl accident victims. Purpose: to study tumor-associated oncogene expression, level of DNA methylation in cancer substrate, level of DNA-ese, single-stranded and double-stranded breaks of DNA. Methods: clinical, biochemical, biophysical, immunological, mathematical. Determine that development it is less the differentiated type of leukemias for children and adults is accompanied by rising of a fraction p53 + cells. Is not marked of point mutations p53 + at leukemias. The rising is detected frequency single-stranded of disruptures DNA for children with leukemias. The direct correlation connection between the content DNA in plasma and quantity of protein in serum and also direct correlation connection between activity DNA - ase and used of cytostatic drugs. In adult with chronic leukemia is exist of demineralization of an bone tissue. Product Description popup.authors popup.nrat_date 2020-04-02 Close