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Information × Registration Number 0301U000680, 0100U002770 , R & D reports Title To study the significance oxidative-stress component of radiation impact upon the state of the central nervous system popup.stage_title Скринінгові дослідження можливості модифікації наслідків радіаційного впливу на стан центральної нервової системи Head Rudnyev Mykhajlo Ivanovych, Registration Date 23-04-2001 Organization Research Centre for Radiation Medicine popup.description2 The goal: identification of the significance of oxidative stress mechanisms of radiation effects on the state of the CNS by application of agents with antioxidant properties at different exposure doses. Object of researches: functional state of the CNS in experimental animals under exposure to ionizing radiation. Methods of research: behavioural, polarographic, electrocalorimetric, spectrophotometric, statistical. Antioxidants (vitamin E, C, b-carotene) usage, according to the data of two-month observation, improves operant performance of exposed (0.1-0.5 Gr) animals under emotion-pain stress. Ponounced membrane stabilizing effect of the preparations and their positive influence upon the processes of lipid peroxidation in animal's brain as well as significant decrease of the signs of oxidative phosphorilation in the brain tissues caused by the exposure were shown. Screening showed the feasibility of b-carotene and tocopherol usage for correction of disturbance of tissue respiration in the brain of expo sed animals Product Description popup.authors popup.nrat_date 2020-04-02 Close