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Information × Registration Number 0302U007554, 0100U003383 , R & D reports Title Investigating the peculiarities of course, dynamic of heart remodeling in Chernobyl disaster survivors with essential hypertension and creating the measures for optimization of diagnostic and treatment popup.stage_title Вивчити динаміку клінічного перебігу гіпертонічної хвороби у постраждалих внаслідок Чорнобильської катастрофи, залежність її особливостей від ремоделювання серця Head Khomazjuk Inna, Registration Date 03-01-2003 Organization Research Centre for Radiation Medicine popup.description2 Object: 104 Chernobyl disaster survivors with prolonged essential hypertension (EH). Aim was determination peculiarities of clinical current prolonged essential hypertension (EH) at the Chernobyl disaster survivors depending on heart remodelling. Methods: clinical inspection, 24-hour blood pressure (BP) monitoring and electrocardiography holter monitoring, 24-hour heart rate variability monitoring, echo-, dopplercardiography, exercise tests for definition of exercise tolerance. Results: regular peculiarities of adverse clinical current H at the Chernobyl disaster survivors are occurrence and progressing left ventricle (LV) diastolic dysfunction and hypertrophy, increasing of a left atrium and LV cavity, deterioration of heart rate variability, reduction of exercise tolerance. Determinants of these changes were an index of loading by (BP) more than 50%, high BP variability and increased speed of morning BP rising, infringement of BP daily structure. In cases of controlled BP during 2 years in 80,4%patients the current EH remained stable. At prolonged EH patients within 1-2 years heart remodelling was characterized with infringement LV diastolic relaxation, increase of an index of the ratio left atrium size to end-diastolic the size more than 0,75, by increase of frequency LV hypertrophy higher than 2 levels. The EH current was accompanied by reduction general heart rate variability, which is characterized with statistical, geometrical and spectral parameters. In one and two years dynamics in cases of stable EH current there was a further reduction of statistical and spectral parameters of heart rate variability, the increased sympathetic activation of heart activity regulation was kept, that promoted to LV hypertrophy progressing and dilatation of its cavity. There was established, that significant heart ectopy revealed with electrocardiography holter monitoring, are connected with more expressed LV hypertrophy. At the Chernobyl disaster survivors with prolonged EH significant increase of intervetricular septum thickness, myocardium mass according ventricular ectopy was established. Reduction exercise tolerance, efficiency of its supply were already occurred at infringements of LF diastolic filling, progressed at LV hypertrophy, increase of a left atrium cavity. Further heart remodelling and connection of coronary heart disease, that was characterized by increase of the LV size and changes of the LV geometrical form. Predictors of exercise tolerance reduction, alongside with the specified factors, there were increases of a LV cavity, LV myocardium mass. Efficiency: the peculiarities of clinical current prolonged EH at the Chernobyl disaster survivors depending on heart remodelling was determined, that will allow on a final stage of work to develop measures on the further optimisation of diagnostics and treatment. Product Description popup.authors popup.nrat_date 2020-04-02 Close