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Information × Registration Number 0303U001102, 0101U000649 , R & D reports Title To study out peculiarity of culture skeleton cells and to determine its role at regeneration of intervertebral disk (experimental investigation) popup.stage_title Дослідження репаративного процесу ушкодженого міжхребцевого диску в умовах трансплантації культивованих скелетогенних клітин Head Radchenko V.A., Registration Date 24-01-2003 Organization Kharkov Scientific-Research Institute of Orthopaedics and Traumatology named after prof. M.I.Sitenko popup.description2 In the "in vitro" experiments during cultivation of mesenchymal cells in high density culture within 9 days we received cells with cartilage phenotype and high biosynthetic activity, synthesizing proteoglycans and collagen. In the experiment on 86 white laboratory rats we took a note that the quantity of transplanted cells has a significant meaning for formating of specific tissue regenerate. Optimal quantity of cells for the defect (6mm3) - 5x107 in 1 ml of suspension. Local damage of zones of intervertebral nucleus pulposus leads to development of significant destructive and dystrophic disorder in the intervertebral disc and to the lowering of its height. Using cultivated cartilage differon cells as biological transplant optimizated of reparation process. 3. Damage zone fills with cartilage regenerate, which is located inside of fibrous ring. Product Description popup.authors popup.nrat_date 2020-04-02 Close