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Information × Registration Number 0304U001726, 0103U001410 , R & D reports Title To learn collagenic frames of an exocellular matrix of an bone tissue for damaged in Chornobyl accident with oncohematological for damaged in Chornobyl accident with oncohematological popup.stage_title Оцінити структурні особливості колагену, одержаного з кісток хворих на онкогематологічну патологію, що постраждали внаслідок Чорнобильської катастрофи Head Bruslova Katerina Mihailovna, Registration Date 24-03-2004 Organization Research Centre for Radiation Medicine popup.description2 . Object: 243 children in the age of till 18 years (123 ill with acute leukemias, which lived in the regions, contaminated by radionuclides, and 120 children, inhabitants of the same locales without oncohematological of pathology)The purpose: to learn structural features of a collagen of bones for ill with oncohematological by pathology, which one have suffered in outcome Chernobyl accident. Methods - clinical, morphological, biochemical, biophysical, immunological, mathematical. By results of activity the changes in a metastructure of a molecula of a collagen, aminoacidic structure for ill with a leukemia are determined. In the acute period of disease the unbalance in the contents of amino acids in serum of a blood ill registers. The contents osteocalcine is reduced as contrasted to normative. Exretion calcium dihydrophosphates and calcium dihydrotetra-phosphates with a urine for ill with a leukemia is heightened. The decrease of efficiency in culture of fibroblasts for ill is determined. The lobe of children with lower as contrasted to by normative parameter of a densitometry of bones is more, than for children of group of matching. The obtained data testify to changes in frame of a collagen, mineral phase of an bone tissue, that shows by density changes of bones. Product Description popup.authors popup.nrat_date 2020-04-02 Close