Search academic texts

Information × Registration Number 0305U005687, 0103U007882 , R & D reports Title Screening of antidepressants and neuroprotectors from the ligands of glutamate receptors and studying of its neurochemical mechnisms action popup.stage_title Пошук антидепресантів і нейропротекторів серед лігандів глутаматних рецепторів і вивчення нейрохімічних механізмів їх дії Head Komissarov Igor V., Registration Date 14-12-2005 Organization Donetsk state medical University named after M. Gorky popup.description2 It was assessed the antagonists of NMDA from tienopyrimidinic derivatives of monocarbonic amino acids (substances serie TSV) and its antidepressive qualities, absence this activity for ligands of polyamine sites NMDA receptors (spermine, arcain), and "prodepressive" qualities of "very fast" blockators of ionic channels of NMDA receptors (substances serie IEM).The last can be used for pharmacological evaluation of potential antidepressants.It was found the quite sufficient blockade of NMDA receptors for antidepressive effect of memantine and blockators of glycine binding sites of NMDA receptors (substances serie TSV) and unsufficient in this effect of monoaminergic component and antioxydative qualities of NMDA receptor ligands. Product Description popup.authors popup.nrat_date 2020-04-02 Close