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Information × Registration Number 0305U005795, 0101U009233 , R & D reports Title Immuno-endothelium and epithelium dependent mechanisms in the development of hyperimmunocomplex syndrome in the experement and clinic popup.stage_title Імуно-ендотеліально-епітеліальнозалежні механізми в розвитку гіперімунокомплексного синдрому в експерименті і клініці Head Chopyak V., Bidjuk M., Kimakovich V., Registration Date 27-12-2005 Organization Danylo Halytsky Lviv National Medical University popup.description2 We performed an investigations of chronic hyperimmunocomplexemia (HICE) model on 220 white rats with administrating of Corvitine. Main pathоgenetic factors of vascular system functional discharge during HICE are changing of cell and humoral immunity, an activation of free-radical processes with neutrophil, monocyte and lymphocyte stimulation, an activation of inducible NO-synthase in these cells and creation of great guantity of reactive able nitrate substances, which intensivity inhibits by Corvitine. It was showed the Corvitine's role in regulation of functional and morfological cell status during of HICE. Our method of Corvitine's administration showes it's endotheliotropic NO-relating peculiarities and could recommended for using in treatment of patients with HICE. Product Description popup.authors popup.nrat_date 2020-04-02 Close