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Information × Registration Number 0307U001500, 0103U004133 , R & D reports Title Influence of ACE gene polymorphism on clinical and hemodynamic features of arterial hypertension and efficacy of treatment popup.stage_title Вплив поліморізму гена АПФ на клініко-гемодинамічні особливості артеріальної гіпертензії та ефективність терапії Head Tseluyko Vira Iosifovna, Доктор медичних наук Registration Date 26-03-2007 Organization The Kharkiv Post-graduate Medical Academy popup.description2 Complex investigation of 350 patients with different forms of arterial hypertension and 50 persons with normal blood pressure (BP) was carried out. It was determined that I/D polymorphism of the ACE gene influences significantly on formation of the salt sensitivity, clinical course of the disease, 24-hour profile of BP and hemodynamic indexes. It was established, that presence of D-allele of the ACE gene is accompanied with negative changes of investigated parameters, especially in the patients with sodium-sencitive arterial hypertension (SSAH). The possibility of SSAH diagnostics basing on the results of 24-hour BP monitoring is substantiated. The negative influence of the gene ACE D-allele and genotype DD on the effectiveness of antihypertensive treatment is shown. In patients with metabolic syndrome X D-allele of the ACE-gene is shown to be assotiated with more severe course of the disease according to the results of 24-hour BP monitoring, indexes of platelet aggregation and lipid metabolism. As a result of the study, differentiated schemes for prescription of antihypertensive treatment to patients with essential hypertension are worked out, according to genetic and associated clinical and hemodynamic characteristics of the patient. The choice of the optimal treatment scheme should be based on results of instrumental and laboratory investigations. Product Description popup.authors popup.nrat_date 2020-04-02 Close