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Information × Registration Number 0307U007921, 0105U008878 , R & D reports Title Complex experimental study of the pharmacological activity of new derivatives of germanium containing compounds with bioligands popup.stage_title Встановити особливості фармакокінетики даних сполук в організмі експериментальних тварин, провести позамодельний порівняльний аналіз їх фармакокінетики та вивчити вплив нових БАР на серцево-судинну систему. Head Kresyun Valentin Iosephovich, Registration Date 05-12-2007 Organization Odessa state medical university popup.description2 The new methods of outmodeling analysis of pharmacokinetics parameters of medications allow on the minimal amount of experimental animals to conduct the summarizing exact estimation of pharmacokinetic properties of BAS. The obtained by new methods information about pharmacokinetic properties of three new derivatives of oxyethylidendiphosphonate germanates testify the significant difference in distribution and excretion depending on their structure and allow to forecast their pharmakodynamic activity. First in vitro and in vivo were probed cardiovasotropic effects of these compounds and it is discovered that magnesium-oxyetthylidendiphosphonate germanate (germakord) possesses high anti-arrhythmic and antihypertensive activities. Product Description popup.authors popup.nrat_date 2020-04-02 Close