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Information × Registration Number 0309U004031, 0108U009695 , R & D reports Title Forming of the registry for patients with malignant hematological diseases and defining of the diseases course pecularities, molecular-genetic characteristics and elaboration of the practical recomendations for the long-term monitoring popup.stage_title Обґрунтувати створення бази верифікованих даних (БД) спеціалізованого локального реєстру онкогематологічних захворювань у постраждалих від наслідків аварії на ЧАЕС та контингентів осіб, що професійно пов'язані з джерелами випромінення з генетичними характеристиками для проведення довгострокового моніторингу на основі оцінки клініко-гематологічних особливостей перебігу та спадково-конституційного статусу. Head Bebeshko Volodimir Grigorovich, Доктор медичних наук Registration Date 16-01-2009 Organization State Institution "Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine" popup.description2 Subject: information technologies for creation of the population and hospital registries, hemoblastoses cases in persons suffered following Chernobyl catastrophe, genetic characteristics of hemoblastoses patients. Aim: Elaborate the main approaches to local registry forming for hemoblastoses registrstion in sufferers folowing Chornobyl accident and persons professioanally linked to the sourses of irradiation for monitoring of hematological malignancies and genetic status of the patients. Methods: Hematological,mathematic, systemic analysis, epidemiological. Results.The main approaches to the local registry creation are worked out.It includes personal monitoring of the cases input to the database, constant and dinamic regular collection of the clinical and pathological information. The individual record structure foreseens the indificators and genetic parameters for the differential diagnostics,risk of appearence and disease course prognosis.It was identified that realisation of the genetic predisposition to pathological process is one of the mechanisms of the post irradiation effects realisation at the level of the immune homeostasis and somatic disorders causally connected to iradiation Radiation factor is inductor of the genetic predisposition of the pathological process. It allaud to estimate it as possible selective-ecological factor, inductor of the long term consequenses on the individual and population levels. Presence in thec genotype alleles HLA-A*24; HLA-A*02 ; DRB1*07; B52 proves the risk of the acute leukemia risk realisation. Presence of the genotypic connection HLA-A*24; HLA-A*02; B*35;В38; Cw*3; DR4 is the risk factor for the disorders in the hemopoesis, bone marrow syndrom realisation and hematological malignancies after irradiation.Presence in the genotype the markers of the radiosensitivity and genetic predisposition to the acute leukemia increases the malignancies realisation risks Product Description popup.authors popup.nrat_date 2020-04-02 Close