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Information × Registration Number 0310U002360, 0106U005894 , R & D reports Title Condensed heterocycles of plant and synthetic origin in the synthesis of new types of bioregulators - the way to drugs of new generation popup.stage_title Трансформації на основі азот- та кисневмісних гетероциклів Head Volovenko Yu. M., Registration Date 15-03-2010 Organization Taras Shevchenko Kiev university popup.description2 The interaction of 3-hetarylsubstituted 5-fluoro--6-nitro-1H-2-indolamines with 1,3-bielectrophils to form 10-hetaryl-8-fluoronitropyrimido-[1,2-a]indoles was investigated . Corresponding 8-aminoderivatives were synthesized by nucleophilic substitution of fluorine. .Cyclocondensation of 1-alkyl-1-H-benzimidazoles, -imidazoles with 1,3-diphenyl-4-bromo-2-buten-1-оn to prepare pyrido[2,1-b]benzimidazole, imidazo[1,2-a]pyridine systems was studied. Novel equivalents of 1,4-bielectrophiles - derivatives o-bromomethylbenzophenone for formation of fused izoquinolines were proposed. New reduction reaction of flavonoids with iridium-catalyst was investigated. Conformationally constrained bicyclic proline analogues were incorporated into antimicrobial peptide Gramicidine S. The synthetic approaches to 1,2,3,4- tetrahydroquinoline-3-carboxylic acids, 3-(2- hidroxybenzoyl)quinolines, 7-H-chromeno[3,2-c]quinolines with trimethylchlorosilan as a condensing agent were elaborated. Product Description popup.authors popup.nrat_date 2020-04-02 Close