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Information × Registration Number 0311U003270, 0109U000436 , R & D reports Title 3. To elaborate systematic science measures to increase of effectiveness of cytologic diagnosis of precancer and cancer of cervix uteri popup.stage_title Вивчити цитогенетичні показники епітелія шийки матки при помірній і тяжкій дисплазії та співставити їх з цитоморфологічними ознаками. Визначити характерні цитогенетичні ознаки помірної і тяжкої дисплазії епітелія шийки матки. Head 3. Bolgova Lydiya Sevastiyanovna, Registration Date 25-02-2011 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 3. Object of study - patients with precancer and cancer of cervix uteri and without revealed pathology (smears of cervix uteri and cervical canal, cytological and histological preparations). The aim - to develop scientifical systematic measures directed on elevation of the efficacy of cytologic diagnostic of precancerous state and cancer of cervix uteri. The methods of study: cytologic, cytogenetic, histological, statistical. Apparatus: microscopes OLYMPUS - СХ 21, СХ 41, ВХ 41, Nikon Esclipe 80, computer Flatron, printer Canon Laser Shot LBP-112000. It has been shown that along with appearance and development of dysplasia signs in population of cells of cylindrical and squamous epithelium the total number of active morphofunctional types of nucleoli increases, what objectives cytomorphological signs and evidences on malignant transformation of epithelial cells. The use of cytologic and cytogenetic methods of study allowed to reveal gradual increase of the number of active compact and transitional nucleolonemic nucleoli in nuclei of squamous epithelial cells of cervix uteri with signs of dysplasia of different degrees. That fact points on essential increase of nucleoprotein exchange what is typical for malignant process. The performed studies have allowed to reveal the cytogenetic parameters of different degrees of dysplasia, for the comparison of which with the respective data for cervical cancer further scientific search is required. Medicine. Product Description popup.authors Алексєєнко Оксана Іванівна Грабовий Олександр Миколайович Тиха Наталія Борисівна Туганова Тамара Миколаївна Ярощук Тетяна Михайлівна popup.nrat_date 2020-04-02 Close