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Information × Registration Number 0311U003366, 0108U001581 , R & D reports Title Investigation of the mechanisms of ineffective haemopoesis and its interrelation with biological features of blood cells and bone marrow in myelodysplastic syndrome. popup.stage_title Відбір хворих для обстеження, проведення комплексу досліджень з визначення цитологічних та імунофенотипових характеристик при різних підтипах МДС Head Masliak Zvenyslava Volodymyrivna, Registration Date 09-03-2011 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 The paper comprises results of investigation of 14 patients with different subtypes of MDS. According to FAB-classification 11 of them were diagnosed with RA, one had RAEB, another patient was diagnosed with RAEB-t and 1 was confirmed with RA/fibrosis. The patients were also subdivided into IPSS risk groups with 3 high-risk patients, 4 - intermediate risk I subjects and 1 patient belonging to intermediate risk II subgroup. Cytogenetic investigation revealed genomic abnormalities in 3 studied patients. Anemia of different severity grades was found in 13 patients whereas normal hemoglobin level was stated only in 1 patient. Level of the white blood cells ranged from 0.9 to 5.4 x109/L, only one case of leukocytosis up to 13.1 x 109/L was found. Absolute platelet count was quite variable in the studied group with hyperthrombocytosis in RA/fibrosis patient and singular platelets in patient with RAEB-t. Patients who underwent bone marrow biopsy had their diagnosis confirmed. Treatment of the subjects included red blood cell transfusions (14 patients), the frequency of this procedure depended on severity of anemia; corticosteroids (13 patients); 3 patients received erythropoiesis stimulating agents (Recormon, Eprex); 5 patients were treated with Cyclosporine A. One of RA patients who belonged to the IPSS low risk group died of acute coronary syndrome; one case of transformation to ALL (confirmed by cytochemical tests) was revealed; in another case diagnosis of paroxysmal nocturnal hemoglobinuria was suspected. The patient with RA who was revealed with significant cytogenetic abnormalities (intermediate risk group II) developed peripheral blood blastosis (8% of blasts). This was considered as sign of progression of RA to RAEB-t. Product Description popup.authors Бойко Ольга Ігорівна Виговська Ярослава Іллівна Даниш Ольга Йосипівна Кароль Юрій Степанович Котлярчук Костянтин Богданович Лещук Остап Васильович Мазурок Анна Антонівна Мельник Марія Іллярівна Томашевська Наталія Яремівна Цяпка Орест Миколайович popup.nrat_date 2020-04-02 Close