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Information × Registration Number 0311U003737, 0106U003974 , R & D reports Title Study of structure and properties of carbohydrates and compounds containing carbohydrates and biopolymers. popup.stage_title Вивчення будови і властивостей вуглеводів та вуглеводовмісних сполук і біополімерів Head Chirva Vasyl' Yakovych, Registration Date 02-06-2011 Organization National Taurida V. Vernadsky University popup.description2 The basic laws catalyzed by crown-ethers and polyethylene glycol reactions ?-D-glucosaminyl chloride with connections of the phenolic nature are studied. Established the role of catalysts in the formation of both main and side reaction products. Influence of the nature of solvents, parities of reacting substances, temperature, on exits and structure of products of a glycosylation is investigated. In the phase transfer system "solid calcium carbonate - acetonitrile" are synthesized N-?-D-glucosaminides 3,3-disubstituted 2-оxоindole. The basic laws of process of a glycosilation are studied. Conclusions concerning nature influence aglycone on structure and exits of products of reaction are drawn. Computer forecasting of biological activity is carried out. In system "a firm carbonate of potassium - organic solvent" are synthesized N-?-D-glucosaminidy S-alkil-1,2,4-triazolonov. The basic laws of process of a glycosilation are studied. Conclusions concerning nature influence aglycone on structure and exits of products of reaction are drawn. In system "a firm carbonate of potassium - organic solvent" the basic laws of process of a glycosilation replaced 1,2,4-triazol-3-tionov are studied. Conclusions concerning influence of conditions of a glycosilation on structure and exits of products of reaction are drawn. In interphase catalytic systems reactionary ability various 3-С-substituted 2-oхoindolov in reaction with ?-D-glucosaminyl chloride is investigated. The basic structural features of glycosyl-acceptors providing course of reaction of a glycosylation are established. The synthesis of group O-glucosaminides isatine-3-oximes with free indole nitrogen atom. It is shown that a variation of the nature of a crown-ether allows to receive not only S- but also and N-?-glucosaminidy 2-merkaptobezoхazola. A number glycosidic derivatives of salicylic acid is synthesized, is investigated their anti-inflammatory, psychotropic, antiulcerogenic activity. Are synthesized acetylated conjugates о- и p-carboxyphenyl-N-glucosaminides, and also 1,2:3,4-di-O-isopropyliden-?-D-galactopyranuronic acid with a glycine, ?-alanine, valine, a leucine, methionine, a lysine. Product Description popup.authors Баєвський Михайло Юрійович Земляков Олександр Євгенович Курьянов Володимир Олегович Пертель Сергій Степанович Токарев Михайло Константінович Чупахіна Тетяна Олександрівна Шаповалова Анна Олександрівна popup.nrat_date 2020-04-02 Close