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Information × Registration Number 0311U003905, 0106U003711 , R & D reports Title Тhy synthesis. physycal-chemical properties of imidazole's derivatives and its condensed substitutes popup.stage_title Синтез, фізико-хімічні і біологічні властивості похідних імідазолу та його конденсованих заміщених Head Priymenko B.O., Registration Date 13-09-2011 Organization Zaporozhye State Medical University. Department of psychiatry popup.description2 Investigation object: methylated derivatives of xanthine, their N7- and N1-substituted which have in their structure substituted phenylic substituent, amide, carboxygroups and ilidenhydrazine groups in position 8. 8-aminosubstituted 7-?-hydroxi- - aryloxipropylxanthines. Available methods of synthesis of 1,7,8-substituted of xanthine - promissory biologically active compounds - were worked out. Reactivity of 1- and 7-substituted 8-bromoxanthines concerning to N-, O- and S- nucleophiles was studied for the first time, as a result of it none-described derivatives were synthesized. Interaction of 8-hydrazinoxanthines with aromatic and heterocyclic aldehydes and ketones were studied and thus a wide row of none-described derivatives was received. Reactions of electrophilic substitution were studied on the basis of thioxanthine and new simple preparative methods of synthesis of unknown 8-R-thioderivatives of xanthine were worked out. Compounds are received which after additional study may be applied as antioxidants, analgetics, antiinflammatory agents, diuretics, hypocholesteremic drugs Product Description popup.authors Гнатов Микола Іванович Кандибей Костянтин Іванович Стефанова Світлана Стефанівна Шкодв Олександр Станіславович popup.nrat_date 2020-04-02 Close