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0408U005368,
к.мед.н.
26-11-2008
o
The comparative characteristics of clinical pathogenetic signs in multiple sclerosis at different age groups
Shorobura Mariya Stefanivna,
popup.head Negrich Tatyana Ivanovna
popup.opponent Волошина Наталія Петрівна
popup.opponent Євтушенко Станіслав Костянтинович
Дисертація присвячена вивченню нових патогенетичних механізмів розвитку РС у дітей, розробці ефективних діагностичних і прогностичних маркерів цього захворювання й оптимізації підходів до лікувальної тактики хворих. Досліджено особливості клінічного перебігу РС залежно від віку пацієнтів. Доведено провідну роль ІФН-? в процесах пошкодження нервової тканини у дітей з РС, особливо у дівчаток і взаємозв'язок цього показника з клінічними проявами захворювання. Вперше досліджено, що препарати Ig плазми крові хворих на РС дітей володіють підвищеною цитотоксичною активністю щодо імунних людських лейкемічних Т-лімфоцитів порівняно з дорослими хворими, що є прогностично сприятливою ознакою. Визначено важливе значення каталітичної властивості щодо ДНК абзимів плазми крові хворих на РС дітей і довели їх залежність від клінічних особливостей цього захворювання. Обгрунтована клінічна ефективність лікування хворих на РС солу-медролом. Ключові слова: розсіяний склероз, діти, цитокіни, абзими, ДНК.
2008-11-26
2020-04-04
Updated: 2025-12-07
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