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0409U002144,
к.фарм.н.
20-02-2009
o
Experimental study of anti-inflammatory, reparative properties from Alnus glytinosa bark the viscous extract
Reshetnyak Nataliya Valeriyivna,
popup.head Maloshtan Lyudmyla Mykolayivna
popup.opponent Дикий Ігор Леонідович
popup.opponent Киричок Людмила Трохимівна
Дисертація присвячена вивченню протизапальних властивостей густого екстракту з кори вільхи клейкої (ГЕКВК), де теоретично обгрунтована та експериментально доведена антиексудативна, репаративна, антимікробна дія.В експерименті встановлено, що найвищу активність ГЕКВК проявляє у дозі 60 мг/кг маси тварин і пригнічує асептичне запалення, визване карагеніном, на 38,4%, проти препарату порівняння - вольтарен 60,3% (Р<0,05). При вивчені репаративної активності встановлено, що ГЕКВК збільшує міцність рубця в асептичних та інфікованих ранах на 5-у - 7-у добу (78,3% та 62,8%), а препарат порівняння - альтан (43,8% та 52%). Антимікробна дія ГЕКВК найбільш активно проявилась відносно культур грампозитивних бактерій S.auris, S.mitis, Cl.perfringeпs. Вивчаємий екстракт проявляє мембраностабілізувальну, антиоксидантну та капілярозміцнювальну активність, що відбиває уявлення про механізм протизапальної дії ГЕКВК.Вивчена ефективність таблеток екстракту на моделях гострого запалення: стоматит і риніт. В результаті їх застосування відмічено зниження секреції, зменьшення набряку, в клінічному аналізі крові відмічалось зниження кількості лейкоцитів по відношенню до контрольної патології на протязі всього періоду дослідження. Експериментально доказано відсутність у ГЕКВК ульцерогенної, цитотоксичної, алергізуючої та місцевоподразнювальної дії.
2009-02-20
2020-04-04
Updated: 2025-12-07
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