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Information × Registration Number 2112U001671, Article popup.category Thesis Title popup.author popup.publication 01-01-2012 popup.source_user Сумський державний університет popup.source http://essuir.sumdu.edu.ua/handle/123456789/34970 popup.publisher Sumy State University Description The anionic derivative of asymmetric triblock copolymer containing biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) was obtained. The micellization of the initial (TBC) and modified (TBC-COOH) copolymer samples in aqueous solution were investigated. Practically the same values of the critical micellization concentration and the Gibbs free micellization energy for both TBCs were found. The anticancer effects of the doxorubicin (DOX)-loaded micelles of the initial and modified triblock copolymers were studied on the tumor cells of human T-leukemia of Jurkat line, transformed leukemia of L929 line and mouse lymphatic leukemia of L1210 line. The fact of high efficacy of DOX/TBC and DOX/TBC-COOH compositions in compare with pure DOX was determined and discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34970 popup.nrat_date 2025-05-12 Close