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Інформація × Реєстраційний номер 2113U001500, Матеріали видань та локальних репозитаріїв Категорія Thesis Назва роботи The Method for Protein Display on the Surface of Bacterial Magnetic Nanoparticles Автор Дата публікації 01-01-2013 Постачальник інформації Сумський державний університет Першоджерело http://essuir.sumdu.edu.ua/handle/123456789/35488 Видання Sumy State University Опис In this study, we present a comprehensive approach to the design and development of magnetosomes with antibodies immobilized on their surface by integration in membrane in vitro. Designed fusion proteins Mbb and Mistbb consisted of anchor proteins and BB-domains of Staphylococcus aureus protein A as IgG-binding region were used for development of IgG-binding magnetosomes. The magnetosome membrane protein MamC and membrane protein of Bacillus subtilis Mistic were selected as anchor proteins. Using Response Surface Methodology (RSM), the high level of fusion proteins integration into bacterial nanopar-ticles membrane was achieved. IgG-binding magnetosomes obtained through this strategy could serve as multifunctional platform for displaying various types of antibodies. Such systems could be applied as theranostic agents. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35488 Додано в НРАТ 2025-05-12 Закрити