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Information × Registration Number 2121U006518, Article popup.category Тези Title popup.author Lakhtadyr T.Cherkasov V.Turbal L.Doroshchuk S.Kaminskiy R. popup.publication 08-02-2021 popup.source_user Національний медичний університет імені О. О. Богомольця popup.source http://ir.librarynmu.com/handle/123456789/2268 popup.publisher IV th INTERNATIONAL ACADEMIC CONFERENCE, Warsaw Description With deep and significant skin burns, structural and functional disorders occur in almost all organs and systems, leading to the development of burn disease. Among the factors of these changes of cells, tissues, organs and systems of the burned organism are imbalance of water-salt homeostasis and endogenous intoxication. Therefore, for optimal treatment and prevention of the effects of thermal injuries, it is quite reasonable to use infusion solutions to reduce the level of toxins in the body and normalize water-salt metabolism. Among colloidal solutions, the group of hydroxyethylated starches claims to be in the first place, but there is debate over the appropriateness of using some of them in certain clinical situations. That is why there is a need to develop new colloidal solutions of this group and to comparatively study the structural manifestations of their action on the internal organs of burns. Meanwhile, in the scientific literature there are no data on the structural changes of the cortical substance of the kidneys and the course of its regenerative processes in the late period after burn injury of the skin under the conditions of infusion of a new colloid-electrolyte-hyperosmolar drug HAES-LX5%. Research to establish the structural features of damages and compensatory adaptive changes in the renal cortex of rats in the later stages after experimental burn the skin under the conditions of the intravenous infusion of isotonic NaCl solution and integrated hyperosmolar solutions (Lactoproteinum with sorbitol and HAES-LX-5% was conducted 105 white male rats weighing 155-160 g. Aim of research is the establishment of structural features of the course of the adaptive-compensatory and regenerative processes in the cortical substance of the rat kidney in late terms after experimental burn skin injury and the use of HAES-LX-5% is relevant for theoretical and practical medicine. popup.nrat_date 2025-07-28 Close