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Інформація × Реєстраційний номер 2122U003007, Матеріали видань та локальних репозитаріїв Категорія Препринт Назва роботи Brain age prediction based on EEG records Автор Klymenko Mykola Дата публікації 01-01-2022 Постачальник інформації Український католицький університет Першоджерело https://hdl.handle.net/20.500.14570/3157 Видання Опис Ambulatory EEG is a widespread test used in hospitals for the neurological evaluation of patients. EEG waveforms are typically reviewed by a trained neurologist to classify EEG into clinical categories. Methodologically, there is a need to classify EEG recordings automatically. Ideally, the classification models should be interpretable, able to deal with EEG of varying durations, and robust to various artifacts. We aimed to test and validate a framework for EEG classification, which satisfies such requirements by symbolizing EEG signals and adapting a method previously proposed in natural language processing (NLP).We considered an extensive sample of routine clinical EEG (n=5’850), with a wide range of ages between 0 and 100 years old. We symbolized the multi-variate EEG times series and applied a byte-pair encoding (BPE) algorithm to extract a dictionary of the most frequent patterns (tokens) reflecting the variability of EEG waveforms. To demonstrate the performance of such an approach, we used newly-reconstructed EEG features to predict the biological age of patients with Random Forest. We also correlated the relative frequencies of tokens with age. We found that the age prediction model achieved the mean absolute error of 15.9 in years. The correlation between actual and predicted age was 0.56. The most significant correlations between the frequencies of tokens and age were observed at frontal and occipital EEG channels. Our findings demonstrate the feasibility of an approach based on applying NLP methods to time series classification. Notably, the proposed algorithms could be instrumental in classifying clinical EEG with minimal preprocessing and sensitivity to the appearance of short events, such as epileptic spikes. Додано в НРАТ 2025-05-09 Закрити