Пошук академічних текстів

Інформація × Реєстраційний номер 2122U005356, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Morphological features of tubular bones reparative regeneration under the influence of antitumor chemotherapeutics Автор Дата публікації 01-01-2022 Постачальник інформації Сумський державний університет Першоджерело https://essuir.sumdu.edu.ua/handle/123456789/87865 Видання Aluna Publishing Опис The aim: Determination of morphological features of reparative regeneration of diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics in a model experiment. Materials and methods: 96 white nonlinear rats after application of the perforated defect of the femur were administered the appropriate antitumor drug (doxorubicin, 5-fluorouracil, methotrexate) three times with an interval of 21 days. Morphological features of bone tissue formation and remodeling in the regenerate area were studied using histological and morphometric methods. Results: The inhibitory effect of antitumor chemotherapeutics on the formation of regenerate, expressed by slowing down the process of bone tissue differentiation was found. This is confirmed by a decrease in the area of reticulofibrous and lamellar bone tissue, chaotic arrangement and narrowing of bone trabeculae with uneven color, slow formation of bonding lines between the maternal bone and the regenerate. Conclusions: The revealed morphological features of reparative regeneration of the diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics doxorubicin, 5-fluorouracil and methotrexate in a model experiment indicate a slowing of reparative regeneration processes at all stages of recovery after injury. Додано в НРАТ 2025-05-12 Закрити