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Інформація × Реєстраційний номер 2122U005579, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury Автор Krotov V.Medvediev V.Abdallah I.Bozhenko A.Tatarchuk M.Ishchenko Y.Pichkur L.Savosko S.Tsymbaliuk V.Kopach O.Voitenko N. Дата публікації 09-12-2022 Постачальник інформації Національний медичний університет імені О. О. Богомольця Першоджерело http://ir.librarynmu.com/handle/123456789/4671 Видання Bioengineering Опис Motor disability is a common outcome of spinal cord injury (SCI). The recovery of motor function after injury depends on the severity of neurotrauma; motor deficit can be reversible, at least partially, due to the innate tissue capability to recover, which, however, deteriorates with age. Pain is often a comorbidity of injury, although its prediction remains poor. It is largely unknown whether pain can attend motor dysfunction. Here, we implemented SCI for modelling severe and moderate neurotrauma and monitored SCI rats for up to 5 months post-injury to determine the profiles of both motor deficit and nociceptive sensitivity. Our data showed that motor dysfunction remained persistent after a moderate SCI in older animals (5-month-old); however, there were two populations among young SCI rats (1 month-old) whose motor deficit either declined or exacerbated even more over 4–5 weeks after identical injury. All young SCI rats displayed changed nociceptive sensitivity in thermal and mechanical modalities. The regression analysis of the changes revealed a population trend with respect to hyper- or hyposensitivity/motor deficit. Together, our data describe the phenotypes of motor deficit and pain, the two severe complications of neurotrauma. Our findings also suggest the predictability of motor dysfunction and pain syndromes following SCI that can be a hallmark for long-term rehabilitation and recovery after injury. Додано в НРАТ 2025-06-30 Закрити