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Інформація × Реєстраційний номер 2123U001949, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Comparative analysis of the efficacy of definitive chemoradiation therapy and surgery followed by adjuvant radiation therapy in advanced-stage oral tongue cancer Автор Kravets O.Protsyk V.Burtyn O.Hurianov V. Дата публікації 19-05-2023 Постачальник інформації Національний медичний університет імені О. О. Богомольця Першоджерело http://ir.librarynmu.com/handle/123456789/7621 Видання Experimental Oncology Опис The aim of the study was to compare the efficacy of definitive chemoradiation therapy (CRT) and primary surgery followed by adjuvant radiotherapy (RT) or CRT in the management of patients with stage III–IVA–B resectable oral tongue squamous cell carcinoma (OTSCC). Materials and Methods: It is a retrospective analysis of the treatment outcomes of 211 patients with stage III–IVA–B resectable OTSCC. The patients were divided into two groups depending on the treatment modality: 114 patients received surgery followed by adjuvant RT or CRT (S-RT/CRT) group; the definitive CRT group consisted of 97 patients. Results: The five-year overall survival (OS) was 57.0% in S-RT/CRT group vs 20.4% in CRT group; the five-year disease-free survival (DFS) in S-RT/CRT group was 56.5% vs 15.5%, in the CRT group. Comparison of survival curves revealed statistically significant higher OS and DFS rates in patients of S-RT/CRT group as compared with those in CRT patients (hazard ratio = 0.33 (95% confidence interval 0.23–0.47), p < 0.001 vs hazard ratio = 0.25 (95% confidence interval 0.17–0.37), p < 0.001). A multivariate analysis showed a statistically significant prognostic effect of the primary tumor extension cT4 (p = 0.004), cervical lymph node involvement cN2 (p < 0.001), cN3 (p = 0.04) and treatment modality (p < 0.001) on OS. There was also found a statistically significant prognostic effect of the primary tumor extension cT4 (p = 0.02), cervical lymph node involvement cN2 (p < 0.001) and treatment modality (p < 0.001) on DFS. 18 (15.8%) patients of S-RT/CRT group and 13 (13.4%) patients (p = 0.77) of CRT group developed mandibular osteoradionecrosis. Conclusion: Primary surgery with adjuvant RT or CRT in ad vanced-stage resectable OTSCC significantly increases five-year OS and DFS rates as compared to those after definitive CRT. Додано в НРАТ 2024-12-23 Закрити