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Інформація × Реєстраційний номер 2123U009240, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи ER22/23EK and TTH111I polymorphisms in the glucocorticoid receptor gene in patients with bronchial asthma with regard to the age of onset Автор Дата публікації 01-01-2023 Постачальник інформації Сумський державний університет Першоджерело https://essuir.sumdu.edu.ua/handle/123456789/93763 Видання Georgian Medical News Опис The objective of the study was to evaluate the frequency of the ER22/23EK and Tth111I polymorphisms in the glucocorticoid receptor gene (GR) in patients with early onset and late-onset asthma (BA) and to assess the risk of its phenotype’s development. The analysis of frequency of genotypes and alleles for the ER22/23EK polymorphism in the GR gene with regard to the age of BA onset demonstrated a significant difference between patients with early-onset and late-onset asthma (p = 0.035). A significant difference was revealed in the distribution of alleles and genotypes for the Tth111I polymorphism in the GR gene between patients with early-onset BA and late-onset BA (p = 0.006). No correlation was found between the ER22/23EK polymorphism in the GR gene and late-onset BA in all genetic models; also, there was a reduction in the risk of early-onset BA observed in the dominant and additive models. No association was demonstrated between the Tth111I polymorphism in the GR gene and late-onset asthma, while a statistically significant correlation was shown with the risk of early-onset asthma in the dominant and super-dominant models. Додано в НРАТ 2025-05-12 Закрити