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Інформація × Реєстраційний номер 2123U009569, Матеріали видань та локальних репозитаріїв Категорія Інше Назва роботи Molecular mechanisms of interaction of hypoxia with endoplasmic reticulum stress signaling pathways Автор Sliusar M.Minchenko D.Luzina O.Khita O.Minchenko O. Дата публікації 14-06-2023 Постачальник інформації Національний медичний університет імені О. О. Богомольця Першоджерело http://ir.librarynmu.com/handle/123456789/8150 Видання 5-а Міжнародна наукова конференція “Актуальні проблеми сучасної біохімії, клітинної біології та фізіології ” Опис The aggressive phenotype of glioblastoma multiforme may be associated with hypoxia, which plays a key role in tumorigenesis through changes in gene expression controlled by the hypoxia inducible factor 1 (HIF-1). The rapid growth of solid tumors generates microenvironmental changes in regards to processes relying on the activation of endoplasmic reticulum stress signaling pathways. It is well known that suppression of the function of IRE1/ERN1 (inositol requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) branch of endoplasmic reticulum stress has been demonstrated to result in significant anti-proliferative effect in glioma growth. IRE1 regulates the transcription of a large number of genes through transcription factor XBP1 (X-box binding protein 1). Thus, the goal of our study was to evaluate the effect of hypoxia on the expression of genes that play an essential role in tumorigenesis, namely IDH2 (isocitrate dehydrogenase (NADP+), NNT (nicotinamide nucleotide transhydrogenase), SLC1A1 (solute carrier family 1 member 1), high-affinity mitochondrial glutamate transporters that also play an essential role in transporting glutamate across plasma membranes, SLC1A3 (solute carrier family 1 member 3), glutamate transporter, also known as excitatory amino acid transporters (EAATs), and widely distributed throughout the brain, SLC1A4 (solute carrier family 1 member 4), and SLC25A12 (solute carrier family 25 member 12), which controls glutamate transporter and gluconeogenesis, as well as microRNA miR-182-5p, which have specific binding sites in mRNA SLC1A1, in response to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 in U87 glioma cells; identify binding sites for XBP1 and HIF transcription factors in promoter region of a subset of genes by bioinformatics analysis. Додано в НРАТ 2025-06-30 Закрити