Реєстраційний номер
2123U012459, Матеріали видань та локальних репозитаріїв
Категорія
Текст
Назва роботи
Respiratory microbiome and its relationship with inflammatory markers
Автор
Horlenko Olesya M.
Pikina Iryna Yu.
Prylypko Lyubomyra B.
Kossey Gabriella B.
Derbak Maria A.
Tomey Adrian I.
Mashyka Volodymyr Yu.
Горленко Олеся Михайлівна
Пікіна Ірина Юріївна
Прилипко Любомира Богданівна
Коссей Габріелла Барнабашівна
Дербак Марія Антонівна
Томей Адріан Іванович
Машіка Володимир Юрійович
Horlenko Olesya M.
Pikina Iryna Yu.
Prylypko Lyubomyra B.
Kossey Gabriella B.
Derbak Maria A.
Tomey Adrian I.
Mashyka Volodymyr Yu.
Horlenko Olesya Mykhailivna
Pikina Iryna Yuriivna
Prylypko Liubomyra Bohdanivna
Kossei Habriella Barnabashivna
Derbak Mariya Antonivna
Tomei Adrian Ivanovych
Mashika Volodymyr Yuriiovych
Дата публікації
01-01-2023
Постачальник інформації
Ужгородський національний університет
Першоджерело
https://dspace.uzhnu.edu.ua/jspui/handle/lib/59912
Видання
Опис
The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship
with inflammatory markers.
Materials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out.
The control group consisted of 25 healthy children identical in age and examination parameters.
Results: When analyzing the microflora of the nasopharynx of patients, 29,0% of strains were gram-positive bacteria and 71,0% were gram-negative bacteria
(Escherichia coli representing 37,0%). Biochemical examination of the biomaterial revealed the presence of sucrase (n=69), maltase (n=87), lactorepoxidase
(n-89) and alcohols - sorbitol (hexahydric alcohol, n=102), mannitol (hexahydric alcohol, n=84), xylitol (pentahydric alcohol, n=86). Regarding the markers
of inflammatory response, the following dynamics was noted: increase in the level of IgM (3,91 ± 1,79 g/l, p<0,01) by 2,2 times, elevation of Ig G level by 10
times (145, 91 ± 53,04 g/l, p< 0,01), slightly higher than the reference values IgE level. In addition, increased IL-1, IL-4, IL-6, γ-IFN, TNF-α, Neopterin levels
were detected. The level of Thyroid stimulating hormone (TSH) was significantly different compared to the control group (0,62 ± 0,57 vs. 1,98 ± 0,30 mIU/
ml, p< 0,01), but within the reference values.
Conclusions: Predominance of Gram-negative bacteria in the nasopharyngeal microflora of patients along with elevated inflammatory markers and lactoperoxydase
enzyme predominance was detected in the study.
Додано/оновлено в НРАТ
2026-06-13
