Реєстраційний номер
2125U008502, Матеріали видань та локальних репозитаріїв
Категорія
Стаття
Назва роботи
Arg16Gly polymorphism in the β2-adrenoceptor gene in patients with bronchial asthma
Автор
Качковська Владислава Володимирівна
Ковчун Анна Володимирівна
Моісеєнко Ірина Олегівна
Дудченко Ірина Олександрівна
Приступа Людмила Никодимівна
Kachkovska Vladyslava Volodymyrivna
Kovchun Anna Volodymyrivna
Moiseyenko Iryna Olehivna
Dudchenko Iryna Oleksandrivna
Prystupa Liudmyla Nykodymivna
Дата публікації
21-07-2025
Постачальник інформації
Сумський державний університет
Першоджерело
https://essuir.sumdu.edu.ua/handle/123456789/99960
Видання
ALUNA Publishing
Опис
The aim: The objective of the study was to analyze the frequency of Arg16Gly polymorphism in the β2-adrenoceptor (β2-АR) gene in patients with bronchial asthma (BA) and to assess the association of the polymorphism with BA risk.
Materials and methods: We examined 553 BA patients and 95 apparently healthy individuals. Arg16Gly polymorphism in the β2-АR gene (rs1042713) was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Statistical analysis of obtained results was performed using SPSS–17 program.
Results: It was established that distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes for Arg16Gly polymorphism in the β2-АR gene was 44.2%, 40.0%, 15.8% in the control group vs. 31.3%; 45.7% and 23.0 among BA patients, respectively (χ2 = 6.59; р = 0.037). No significant difference was observed with regards to the distribution of genotypes for Arg16Gly polymorphism in the β2-АR gene in men and women controls (χ2 = 4.05; р = 0.13) and BA patients (χ2 = 4.34; р = 0.11). BA risk was 1.74 times higher in the minor allele carriers (Arg/Gly + Gly/Gly genotypes) for Arg16Gly polymorphism in the β2-АR gene.
Conclusions: Analysis of Arg16Gly polymorphic variants in the β2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma. No difference with regard to gender was found in the distribution of genotypes.
Додано/оновлено в НРАТ
2026-05-13
