Реєстраційний номер
2126U001607, Матеріали видань та локальних репозитаріїв
Категорія
Стаття
Назва роботи
Церебропротекторний потенціал трансплантації ембріональних фібробластів щура при терапії експериментального гострого ішемічного інсульту
Автор
Konovalov S.
Moroz V.
Yoltukhivskyi M.
Gadzhula N.
Cherepakha O.
Konovalov S.
Moroz V.
Yoltukhivskyi M.
Gadzhula N.
Cherepakha O.
Дата публікації
01-01-2026
Постачальник інформації
Вінницький національний медичний університет ім. М. І. Пирогова
Першоджерело
https://dspace.vnmu.edu.ua/123456789/12035
Видання
Eastern Ukrainian Medical Journal
Опис
Ischemic stroke is one of the major neurological diseases with high disability and mortality rate. The development of ischemic brain injury involves a cascade of complex pathological processes that lead to
reduced oxygen and nutrient supply to the brain, causing an energy deficit in neurons, followed by oxidative stress, inflammation, and apoptosis. However, current approaches to the treatment of ischemic stroke are based on intravenous thrombolysis, surgical thrombectomy, and neuroprotection, but only a limited number of patients have the opportunity to receive these urgent procedures. Therefore, the development of new methods in the treatment of ischemic stroke is
considered a pressing issue in modern medicine. In recent years, a new therapeutic strategy using stem cells has gained attention in stroke treatment. Current approaches to cell therapy for stroke are mostly
limited to the transplantation of autologous bone marrow or adipose-derived stem cells. Embryonic stem cells demonstrate the ability to differentiate into various types of somatic cells, in particular into certain neuronal lineages, which may serve as a new cell source for cell
therapy of degenerative nervous system diseases. Additionally, they secrete extracellular vesicles containing DNA, RNA, and proteins. The
neuroprotective and neuroregenerative potential of stem cells in ischemic stroke is characterized by neurogenesis, angiogenesis, and synaptic plasticity, which positively affects functional recovery following
cerebral ischemia and ischemic-reperfusion injuries. However, according to experimental studies conducted to date, transplantation of stem cells in ischemic stroke still raises unresolved questions regarding its efficacy
depending on cytological origin, optimal delivery routes, dosage, timing of administration after stroke onset, and transplantation frequency.
Додано/оновлено в НРАТ
2026-09-24
