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Інформація × Реєстраційний номер 2121U009066, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Disorders of neuromediator pool in patiens with multifocal atherosclerosis Автор Lyzogub V.Savchuk O.Kupchynska O.Motsak T.Lyzogub V.Savchuk O.Kupchynska O.Motsak T. Дата публікації 01-01-2021 Постачальник інформації Національний медичний університет імені О. О. Богомольця Першоджерело http://ir.librarynmu.com/handle/123456789/5485 Видання Опис In 62 patients with multifocal atherosclerosis of men of average age (72.3±3.3) years, blood flow parameters in peripheral arteries, serotonine, histamine, dophamine, beta–endorphins in serum and serotonine in plasma. Found a significant decrease in volumetric blood flow in the arteries carotis interna, mesenterica superior, femoralis communis, tibialis posterior; the levels of serotonine, histamine, dophamine in the serum significantly exceeded their maximum values of almost healthy individuals (control group, n=19), respectively, 4.6, 4.3 and 3.5 times. Taking cilostazol for 12 weeks contributed to a significant (p<0.001) increase in volumetric blood flow in the studied arteries: – in arteries carotis interna by 18.2 %, in arteria mesenterica superior – by 17.8 %, in arteria femoralis communis – by 18.8 %, in arteria tibialis posterior – by 69.4 %, which was accompanied by an improvement in the clinical manifestations of the disease, a significant decrease plasma serotonine level (by 2.9 times; p<0.001) and serotonine (by 39.0 %; p<0.05) and histamine (by 62.1 %; p<0,01) in blood serum, increase beta–endorphin level (by 29.8 %; p<0,01). Serum dophamine levels did not change significantly. The role of neurotransmitters in the course of multifocal atherosclerosis is discussed; the pharmacotherapeutic possibilities of cilostazol are analyzed. Додано в НРАТ 2026-04-22 Закрити