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Information × Registration Number 0221U106708, 0120U104577 , R & D reports Title Development of the scientific grounds for the biotechnological production of novel hypotensive and antiarrhythmic alkaloids from Rauwolfia serpentina Benth. popup.stage_title Head Kunakh Viktor A., Доктор біологічних наук Registration Date 17-12-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2  Relaxing action of the Fraction 4 (containing mainly vomilenine, methylajmalicine, ajmalicine, and raufloridine; total alkaloid content of 65.0%) and Fraction 5 (containing mainly acetylajmaline; total alkaloid content of 47.4%) of alkaloid extracts from Rauvolfia serpentine tissue culture was found in vitro, however the changes in mean blood pressure did not exceed 20%. The Fractions 4 and 5 had a significant antiarrhythmic effect in the model of adrenaline-induced arrhythmias. The antiarrhythmic activity of Fraction 5 was confirmed in the model of ischemic and reperfusion arrhythmias. Product Description popup.authors Andrieiev Ihor O. Bieda Oleksandr A. Vdovin Vasyl S. Kandyba Viktoriia A. Konvalyuk Iryna I. Lukashov Serhii S. Mozhylevska Ludmyla P. Khromov Olexandr Stanislavovich Yarmolyuk Sergiy Mykolayovych popup.nrat_date 2021-12-17 Close
R & D report
Development of the scientific grounds for the biotechnological production of novel hypotensive and antiarrhythmic alkaloids from Rauwolfia serpentina Benth.
Head: Kunakh Viktor A.. Development of the scientific grounds for the biotechnological production of novel hypotensive and antiarrhythmic alkaloids from Rauwolfia serpentina Benth.. (popup.stage: ). Institute of Molecular Biology and Genetics of NAS of Ukraine. № 0221U106708
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Updated: 2026-03-17


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